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  • Title: Fibrinogen and plasminogen modifications during oral estradiol replacement therapy.
    Author: Conard J, Gompel A, Pelissier C, Mirabel C, Basdevant A.
    Journal: Fertil Steril; 1997 Sep; 68(3):449-53. PubMed ID: 9314913.
    Abstract:
    OBJECTIVE: To assess the effects of oral E2 replacement therapy on various hemostatic parameters and cardiovascular risk factors in healthy, postmenopausal women. DESIGN: A double-blind, randomized, prospective study comparing the effect of a placebo and of oral micronized E2 (2 mg daily) during a 6-month period. Evaluations were performed before treatment and after 3 and 6 months. SETTING: Departments of Gynecology, Hemostasis, and Nutrition, Hôtel-Dieu, Paris, France. PATIENT(S): Thirty-six healthy women with natural or surgical menopause. RESULT(S): Compared with placebo, oral E2 replacement therapy resulted in a significant decrease in fibrinogen and apo B and a significant increase in plasminogen. CONCLUSION(S): Besides the effects on lipoproteins, oral estrogen replacement therapy modifies parameters involved in coagulation and fibrinolysis.
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