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  • Title: Anxiety and depressive symptoms in childhood--a genetic study of comorbidity.
    Author: Thapar A, McGuffin P.
    Journal: J Child Psychol Psychiatry; 1997 Sep; 38(6):651-6. PubMed ID: 9315975.
    Abstract:
    Anxiety and depressive symptoms commonly co-occur yet the underlying mechanisms for this covariation remain poorly understood. Genetic strategies are a useful means of investigating whether the comorbidity of two sets of symptoms or disorders can be explained by the same aetiological factors. In this paper we use a systematically ascertained sample of 172 twin pairs aged 8 to 16 years to examine the causes of covariation of maternally rated anxiety and depressive symptoms. The results suggest that most of the covariation can be explained by a common set of genes that influence anxiety and depressive symptoms. Some covariation between anxiety and depressive symptoms is also explained by environmental influences of the non-shared type. In addition, depressive symptoms also appear to be influenced by specific genetic factors.
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