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  • Title: Absorption of ampicillin derivatives from the bovine udder.
    Author: Ziv G.
    Journal: Isr J Med Sci; 1976 Mar; 12(3):260-3. PubMed ID: 931723.
    Abstract:
    The rates at which ampicillin, amoxycillin, metampicillin, hetacillin, and pivampicillin are absorbed from the bovine udder were compared, with the absorption rate of (14C)urea as reference. Straight-line semilogarithmic plots of the percentage of unabsorbed drug against time were obtained, suggesting first-order kinetics for the absorption process. Ampicillin, metampicillin and hetacillin were most slowly absorbed. Amoxycillin was absorbed twice as fast as ampicillin. Pivampicillin was absorbed most rapidly-at more than three times the rate of ampicillin.
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