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  • Title: Isolation of brevistin, a new peptide antibiotic. Studies on antibiotics from the genus Bacillus. IX.
    Author: Shoji J, Sakazaki R, Wakisaka Y, Koizumi K, Mayama M.
    Journal: J Antibiot (Tokyo); 1976 Apr; 29(4):375-9. PubMed ID: 931805.
    Abstract:
    A new peptide antibiotic, brevistin, was isolated from the culture broth of Bacillus brevis 342-14. Brevistin is an acylpeptide with an approximate empirical formula of C63H91N15O18 containing aspartic acid, threonine, glycine, valine, isoleucine, phenylalanine, tryptophan and 2,4-diaminobutyric acid. The antibiotic is soluble in acid and alkaline water. Its hydrochloride is soluble in methanol. Brevistin is active against Ggam-positive bacteria in vitro and in vivo, and is of low toxicity to mice.
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