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  • Title: The prevalence of hepatitis C virus antibodies in thalassemic patients in the south of Thailand.
    Author: Laosombat V, Pornpatkul M, Wongchanchailert M, Worachat K, Wiriyasatienku A.
    Journal: Southeast Asian J Trop Med Public Health; 1997 Mar; 28(1):149-53. PubMed ID: 9322298.
    Abstract:
    One hundred and one thalassemic patients, 37 with homozygous beta-thalassemia, 60 with beta-thalassemia Hb E and 4 with hemoglobin H disease with Hb Constant Spring were studied. Twenty-four of 101 (23.8%) tested positive for antibody to hepatitis C virus (anti-HCV). Anti-HCV positivity among those with homozygous beta-thalassemia was significantly higher than anti-HCV positivity among the beta-thalassemic Hb E group. The number of blood transfusions received by anti-HCV positive thalassemic patients was significantly higher than that by anti-HCV negative thalassemic patients. Ninety per cent of anti-HCV positive thalassemic patients had persistently or intermittently raised SGPT levels.
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