These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Frequency-dependent conduction delay of motor-evoked potentials in multiple sclerosis.
    Author: Nielsen JF.
    Journal: Muscle Nerve; 1997 Oct; 20(10):1264-74. PubMed ID: 9324083.
    Abstract:
    Paired transcranial magnetic stimulation was applied in 33 multiple sclerosis (MS) patients and in 21 healthy controls. A major abnormality was found in latency of the second motor-evoked potential in MS patients. At interstimulus intervals of 75, 100, and 150 ms the central motor conduction time (CMCT) was significantly prolonged in MS patients to 139%, 150%, and 125% of the CMCT of a single magnetic stimulation (P=0.02, P=0.004, P=0.03), respectively. Voluntary contraction of the target muscle abolished the difference in latency independent of the degree of contraction. Stimulation intensity influenced the length of the interstimulus interval during which the maximal conduction delay was obtained. In MS patients there was no correlation between prolonged CMCT to a single magnetic stimulus and the frequency-dependent conduction delay to paired magnetic stimuli. It is hypothesized that the conduction delay of the conditioned response of paired magnetic stimuli in MS is of cortical origin and induced by abnormalities of the ascending volley to the neocortex.
    [Abstract] [Full Text] [Related] [New Search]