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  • Title: Inhibitory effect of furosemide on glucose transport.
    Author: Jung CY, Mookerjee BK.
    Journal: J Lab Clin Med; 1976 Jun; 87(6):960-6. PubMed ID: 932526.
    Abstract:
    The carrier-mediated glucose transport function in the intact human erythrocytes and also that of their isolated membranes is markedly inhibited in the presence of furosemide in vitro. A noncompetitive process is believed to be involved since the transport inhibition was not affected by the presence of high concentrations of glucose in the medium. The inhibition developed slowly over 2 hours. Most of the inhibition was slowly reversed during a 3-hour incubation in medium free of the drug. It is concluded that furosemide inhibits the glucose transport function directly in absence of insulin-mediated transduction mechanism and independently of any interference with intracellular glycolysis.
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