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  • Title: The binding of both [3H]nemonapride and [3H]raclopride is increased in schizophrenia.
    Author: Marzella PL, Hill C, Keks N, Singh B, Copolov D.
    Journal: Biol Psychiatry; 1997 Oct 15; 42(8):648-54. PubMed ID: 9325557.
    Abstract:
    We performed a postmortem autoradiographic study to compare the density of dopamine D4-like sites in caudate putamen section from age-matched schizophrenia (n = 15) and control (n = 15) populations. The densities of the D4-like sites were estimated by subtracting the density of [3H]raclopride (binding D2 and D3 receptors) from the density of [3H]nemonapride (binding D2, D3, and D4 receptors). The findings revealed that in the schizophrenia population there was a significant increase in the binding of both [3H]nemonapride (2.3-fold) and [3H]raclopride (1.9-fold). In addition, in the schizophrenia population the density of D4-like sites was increased 2.6-fold.
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