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  • Title: Prolonged survival of rat skin allograft by treatment with FK506 ointment.
    Author: Fujita T, Takahashi S, Yagihashi A, Jimbow K, Sato N.
    Journal: Transplantation; 1997 Sep 27; 64(6):922-5. PubMed ID: 9326422.
    Abstract:
    BACKGROUND: We studied the effect of FK506 ointment on rat skin allograft survival. METHODS: Lewis rat (RT1(1)) skin allografts were histologically evaluated on day 7 after transplantation to recipient ACI (RT1a) rats. We set histological gradings for rejection as follows: grade 1, intraepidermal blister formation; grade 2, incomplete epidermal separation from the dermis; and grade 3, complete epidermal separation from the epidermis. According to these histological criteria, the immunosuppressive effect of FK506 ointment was assessed. RESULTS: Our data indicated that all recipient rats without FK506 ointment showed grade 3 rejection on day 7 after transplantation. In contrast, the allografts treated with FK506 ointment showed grade 1 rejection. Furthermore the blood concentration of FK506 was below 0.5 ng/ml, minimizing the systemically adverse effects of FK506. CONCLUSIONS: Thus, the present study suggests that the topical administration of FK506 on the skin allografts may be useful and effective in the suppression of skin allograft rejection.
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