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  • Title: ApoE genotype and Alzheimer's disease in adults with Down syndrome: meta-analysis.
    Author: Prasher VP, Chowdhury TA, Rowe BR, Bain SC.
    Journal: Am J Ment Retard; 1997 Sep; 102(2):103-10. PubMed ID: 9327086.
    Abstract:
    The apoE gene polymorphism was examined in 100 adults with Down syndrome (with and without dementia) compared to 346 control subjects without mental retardation. Meta-analysis of available data (480 subjects) revealed that apolipoprotein E genotype distribution for people with Down syndrome was similar to that of the nonretarded population. Although no significant association between possession of the apoE epsilon 4 allele and onset of Alzheimer's disease was found, subjects with the allele had a tendency towards lower age of onset of dementia. Subjects with apoE epsilon 2 allele may not develop dementia and may have increased longevity.
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