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  • Title: Human herpesvirus-8.
    Author: Gillison ML, Ambinder RF.
    Journal: Curr Opin Oncol; 1997 Sep; 9(5):440-9. PubMed ID: 9327222.
    Abstract:
    Our current understanding of Kaposi's sarcoma (KS) has evolved from initial descriptions of this "idiopathic sarcoma" to a progressively detailed characterization of its probable infectious origin. This article traces the explosive discovery of human herpesvirus-8 (HHV-8) and its etiologic associations with KS, Castleman's disease, and primary effusion lymphomas. A framework for understanding how viral infection leads to development of these unusual disease is presented. The possible role of HHV-8 in tumorigenesis, through viral manipulation of signal transduction pathways and cell cycle control, is discussed.
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