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  • Title: The relationship of conjoint traits of dyslipidemias between young offspring and their parents in a community-based sample.
    Author: Chen W, Srinivasan SR, Bao W, Wattigney WA, Berenson GS.
    Journal: Prev Med; 1997; 26(5 Pt 1):717-23. PubMed ID: 9327482.
    Abstract:
    BACKGROUND: The relationship of dyslipidemias between young offspring and their parents was examined to evaluate its usefulness in predicting lipid disorders among parents and children. METHODS: Young offspring ages 5-17 years and their parents were studied in a community-based sample of 477 families. The dyslipidemias were defined as: (1) isolated high low-density lipoprotein cholesterol (LDL-C); (2) isolated high triglycerides (TG) and/or low high-density lipoprotein cholesterol (HDL-C); and (3) combined, involving both above. RESULTS: Children of parents with a given dyslipidemia type had the highest frequency of the same disorder (P < 0.001 to P < 0.05). In discriminant analyses only the corresponding disorders in their parents were selected into the models as significant predictors after controlling parental obesity. In terms of sensitivity, 54.8, 50.0, 66.7, and 69.1% of offspring could be correctly predicted for isolated TG/HDL-C, isolated LDL-C, combined, and any type of disorder, respectively, by the corresponding disorders in both parents. Likewise, the predictability of parent's dyslipidemia from their children's disorder was also modest. CONCLUSION: The conjoint dyslipidemias have familial basis to provide rationale for parents or children to determine their own risk status; however, sensitivity and positive predictive values are not high enough to be useful as a selective screening tool.
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