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  • Title: Paracetamol induced acute interstitial nephritis superimposed on mesangiocapillary glomerulonephritis.
    Author: Trinn C, Szöke B, Tóth T, Nagy J.
    Journal: Acta Physiol Hung; 1996; 84(4):469-70. PubMed ID: 9328634.
    Abstract:
    We report the case of a young alcoholic male whose first renal biopsy disclosed mesangiocapillary glomerulonephritis. One month later he took 1.5 g paracetamol to control the fever. Soon he got hospitalized due to toxicoderma, elevated liver and renal function tests. While the liver enzymes returned to normal, uremia developed. A repeated renal biopsy revealed severe interstitial inflammation, tubular atrophy. Haemodialysis was started and he got steroids (1 mg/kg body weight). He showed considerable recovery of renal function in some weeks. The case points to the possibility that paracetamol-even in therapeutic dosage-might result in hepatic and renal damage in alcoholics.
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