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  • Title: Mesangiocapillary glomerulonephritis in lambs. III. Quantitative and qualitative aspects of immunopathology.
    Author: Gardiner AC.
    Journal: J Pathol; 1976 May; 119(1):11-9. PubMed ID: 932870.
    Abstract:
    Newborn Finnish Landrace lambs subsequently affected with mesangiocapillary glomerulonephritis (MCGN) were deficient in the third component of complement (C'3), serum levels being approximately 5 per cent. of those in unaffected lambs. Hypocomplementaemia persisted until symptoms of renal failure occurred at around 6-8 wk of age. Immunofluorescence examinations of renal cortex with antisera specific for IgG, IgM, IgA, C'3 and fibrin supported previous morphological evidence of a strong similarity between this disease and MCGN in man. Similar examinations of choroid plexus suggested that immune complexes containing IgG, IgM and C'3 were present in the interstitium.
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