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  • Title: Effect of alprazolam and ketamine on seizures induced by two different convulsants.
    Author: Herink J.
    Journal: Acta Medica (Hradec Kralove); 1997; 40(1):9-11. PubMed ID: 9329208.
    Abstract:
    Effect of two anticonvulsants with different mechanism of action, i.e. alprazolam and ketamine, was tested in two types of seizure activity. The first one was induced by N-(3,5-dimethoxy-4-propoxyphenylethyl)-aziridine, the second one by pentylenetetrazol. While alprazolam alleviated both the minimal as well as major paroxysms, ketamine suppressed only major seizures. These effects are discussed in terms of the both N-methyl-D-aspartate and GABA receptors involvement.
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