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  • Title: Reduction of activity of cyanocobalamin in the presence of methylparaben sodium at autoclave temperature.
    Author: Yazdany S, Badii F.
    Journal: J Pharm Sci; 1976 May; 65(5):745-7. PubMed ID: 932949.
    Abstract:
    Reduction of activity of cyanocobalamin (vitamin B12) due to degradation or interaction with methylparaben sodium was measured by UV spectrophotometry and microbial assay. TLC of the heated mixture showed two different spots, which indicate some alteration in the structure of the cyanocobalamin molecule in the presence of methylparaben sodium at 115 degrees for 10 min. The losses were about 20% by UV measurements and 32% by microbial assay. The degree of loss was sufficient to suggest that methylparaben sodium might have considerable influence on the stability of pharmaceutical products containing cyanocobalamin. Methylparaben and sodium chloride had no effect on cyanocobalamin.
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