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  • Title: P53 auto-antibodies in the sera of patients with oral squamous cell carcinoma.
    Author: Friedrich RE, Bartel-Friedrich S, Plambeck K, Bahlo M, Klapdor R.
    Journal: Anticancer Res; 1997; 17(4B):3183-4. PubMed ID: 9329632.
    Abstract:
    AIM: To investigate the sera of patients with oral squamous cell carcinoma (OSCC) for the existence of p53 auto-antibodies. MATERIAL AND METHODS: The sera of thirty-nine OSCC-patients were investigated. All samples were from untreated patients with no history of another neoplastic disease. The sera of nine healthy subjects served as controls. RESULTS: P53 auto-antibodies were not detected both in all healthy subjects and in 20.6% OSCC-patients with their disease at an advanced stage. We prove that the extinction rates for p53 auto-antibodies in OSCC are very weak in the majority of investigated sera (50%) and are not related to tumour stage. CONCLUSION: It is unlikely that p53 auto-antibodies can serve as a prognostic marker of OSCC.
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