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  • Title: Bullous pemphigoid evolving into cicatricial pemphigoid?
    Author: Banfield CC, Papadavid E, Frith P, Allen J, Wojnarowska FT.
    Journal: Clin Exp Dermatol; 1997 Jan; 22(1):30-3. PubMed ID: 9330051.
    Abstract:
    We describe three patients who initially presented with both clinical and immunological findings to support a diagnosis of bullous pemphigoid but whose subsequent course has been that of cicatricial pemphigoid. Mucosal scarring was accompanied by a fall in autoantibody titres in our three patients. These cases illustrate the difficulties clinicians may experience in assigning a specific diagnosis to patients. They also support the concept that bullous pemphigoid and cicatricial pemphigoid are part of a single disease spectrum. The most intriguing question is what specific factors determine the expression of a particular disease phenotype as bullous pemphigoid and cicatricial pemphigoid share target antigens and also the DQ7 allele.
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