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  • Title: Anticonvulsant hypersensitivity syndrome.
    Author: Morkunas AR, Miller MB.
    Journal: Crit Care Clin; 1997 Oct; 13(4):727-39. PubMed ID: 9330838.
    Abstract:
    Anticonvulsant hypersensitivity syndrome (AHS) is an uncommon but potentially fatal adverse effect that can occur from exposure to phenytoin, carbamazepine, or phenobarbital. It has diverse clinical features and a variable presentation which results in a delay in making the diagnosis. The syndrome commonly begins within 3 weeks after initiation of an anticonvulsant. Patients typically present with a constellation of fever, usually followed by the development of a rash of variable severity and type, and lymphadenopathy. In patients presenting with these features, the clinician should have a high index of suspicion for AHS.
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