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  • Title: Structure-function and pathogenesis studies of Streptococcus pyogenes extracellular cysteine protease.
    Author: Burns EH, Marciel AM, Musser JM.
    Journal: Adv Exp Med Biol; 1997; 418():589-92. PubMed ID: 9331720.
    Abstract:
    Replacement of the single cysteine residue (C192) with serine in the Streptococcus pyogenes extracellular cysteine protease (SCP) prevented auto-catalytic processing of the 40-kDa zymogen to the 28-kDa mature form and eliminated proteolytic activity. SCP incubated with human endothelial cells induced a time- and concentration-dependent increase in a 66-kDa gelatinase/type IV collagenase in culture supernatants. Activation of this gelatinase/collagenase may contribute to endothelial cell damage, tissue destruction, and hemodynamic derangement observed in some patients with severe, invasive S. pyogenes infection.
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