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  • Title: Immunosuppressive effects of gallic acid and chebulagic acid on CTL-mediated cytotoxicity.
    Author: Hamada S, Kataoka T, Woo JT, Yamada A, Yoshida T, Nishimura T, Otake N, Nagai K.
    Journal: Biol Pharm Bull; 1997 Sep; 20(9):1017-9. PubMed ID: 9331989.
    Abstract:
    Gallic acid (GA) and chebulagic acid (CA) were isolated from the extract of a herbal medicine, kashi (myrobalans: the fruit of Terminalia chebula) as active principles that blocked the cytotoxic T lymphocyte (CTL)-mediated cytotoxicity. GA and CA inhibited the killing activity of CD8+ CTL clone at IC50 values of 30 microM and 50 microM, respectively. Granule exocytosis in response to anti-CD3 stimulation was also blocked by GA and CA at the equivalent concentrations.
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