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  • Title: Effects of pyridinolcarbamate on the cardiovascular system of the anesthetized dog after bilateral cervical vagotomy.
    Author: Grandison D, Shepard RS, Henry RL.
    Journal: Jpn Heart J; 1976 Jan; 17(1):97-105. PubMed ID: 933351.
    Abstract:
    Pyridinolcarbamate (PDC) was injected at a dose of 10 mg/Kg of body weight into the femoral vein of anesthetized dogs with a bilateral cervical vagosympathotomy. At this dose, it produced a transitory decrease in systolic, diastolic, and mean arterial pressure and an increase in heart rate. In addition, it produced a more prolonged increase in stroke volume, peak aortic flow, cardiac output, and left ventricular minute work. It also lowered peripheral resistance and apparently decreased the vaso-constrictor action of injected norepinephrine (1 mug of active base/Kg of body weight). These data are consistent with the view that PDC has a direct action on the heart that is similar to that of norepinephrine and that PDC blocks the alpha adrenergic receptors of the systemic resistance vessels.
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