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  • Title: [20 years unsuccessful prevention of bipolar affective psychosis recurrence].
    Author: Godemann F, Hellweg R.
    Journal: Nervenarzt; 1997 Jul; 68(7):582-5. PubMed ID: 9333720.
    Abstract:
    A now 73-year-old female patient suffered from bipolar affective disorder for the first time at the age of 28. Despite treatment with all known phase-prophylactic agents (i.e., lithium, carbamazepine, valproate, and various antidepressants) she relapsed frequently. To render matters even more difficult, she easily developed side effects with most medications, particularly anticholinergic ones. In order to reach effective longterm prophylactic treatment, we tried several not yet established therapeutic regimens like clozapine, high-dose L-thyroxine, and maintenance ECT. In this case report we discuss the available literature with special respect to clozapine and maintenance ECT.
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