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  • Title: Cochlear nucleus cell size changes in the dalmatian: model of congenital deafness.
    Author: Niparko JK, Finger PA.
    Journal: Otolaryngol Head Neck Surg; 1997 Sep; 117(3 Pt 1):229-35. PubMed ID: 9334770.
    Abstract:
    We assessed cellular changes in one population of neurons of the cochlear nucleus associated with a form of genetic deafness in deaf dalmatians. Spheric cells from deaf dalmatians and age-matched control (hearing) dogs were analyzed morphometrically. The somatic silhouette of these cells was reduced by 22.1% to 38.1%. The effect on cell size was greater with increased duration of deafness. Because the deaf dalmatian exhibits progressive degeneration of the auditory periphery, shrinkage of spheric cells may reflect the initial influence of attenuated activity of auditory nerve fibers, and sensorineural degeneration with longer periods of deafness.
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