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  • Title: Stimulatory effect of synthetic luminal cholecystokinin releasing factor (LCRF) fragment (1-35) on pancreatic exocrine secretion in conscious rats.
    Author: Miyasaka K, Funakoshi A.
    Journal: Pancreas; 1997 Oct; 15(3):310-3. PubMed ID: 9336797.
    Abstract:
    The effects of a synthetic putative luminal cholecystokinin (CCK) releasing factor (LCRF) fragment (1-35) on pancreatic exocrine secretion were examined in conscious Wistar rats and a mutant strain of rats lacking the CCK-A receptor. Intraduodenal injection of graded doses of the LCRF fragment induced biphasic responses in Wistar rats. The injection of 0.1 microgram of the LCRF fragment produced a maximal response, while 1 microgram produced a lower response. No significant effect was observed in rats lacking the CCK-A receptor. The synthetic LCRF fragment stimulated pancreatic secretion via CCK-A receptors in conscious rats.
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