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  • Title: Varicella vaccination in children after bone marrow transplantation.
    Author: Sauerbrei A, Prager J, Hengst U, Zintl F, Wutzler P.
    Journal: Bone Marrow Transplant; 1997 Sep; 20(5):381-3. PubMed ID: 9339753.
    Abstract:
    Herpes zoster (HZ) is one of the most common complications after bone marrow transplantation (BMT) in children. Apart from treatment with antiviral drugs, effective prevention by active immunization with varicella-zoster virus (VZV) appears to be possible. In this study 15 patients were vaccinated with a live attenuated VZV vaccine (Varilrix) 12-23 months after BMT. The vaccine was well tolerated without adverse reactions. Chickenpox or HZ were not observed for up to 2 years after immunization. Eight out of nine seronegative patients seroconverted and in six virus-specific IgG could still be demonstrated 2 years later. The incidence of VZV diseases in 133 non-immunized children after BMT was 26.3%. Infections usually occurred within 18 months after BMT.
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