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  • Title: [Consumption coagulopathy in a patient with metastatic renal carcinoma (author's transl)].
    Author: Wunderlich J, Thimme W.
    Journal: Med Klin; 1976 May 21; 71(21):912-6. PubMed ID: 933986.
    Abstract:
    Chronic disseminated intravascular coagulation with secondary hyperfibrinolysis occurred in a patient with metastatic renal carcinoma. In the beginning the treatment with heparin was successfull. Heparindosage up to 35 000 E/day could never suppress this process completely. The value of determining thrombintime, concentration of fibrin splitting products, coagulation factors II, V, VII, IX, X and XIII, antithrombins II and III in controlling heparintherapy is discussed. Besides thrombintime and platelets the determination of fibrin splitting products is another substantial factor in controlling treatment of chronic intravascular coagulation. The patient died of myocardial rupture with heart tamponade, caused by a great intramyocardial metastasis.
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