These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia.
    Author: Maeda M, Takagi H, Hattori H, Matsuzaki T.
    Journal: Osaka City Med J; 1997 Jun; 43(1):1-5. PubMed ID: 9343989.
    Abstract:
    Manganese-superoxide dismutase (Mn-SOD) was localized in the cerebral cortex and hippocampus of patients with Alzheimer-type senile dementia (ATD) by immunocytochemistry and the relationship of Mn-SOD with two major pathological features of ATD, i.e., senile plaques and neurofibrillar tangles (NFTs), was examined. Many astrocytes in senile plaques exhibited strong immunoreactivity for both Mn-SOD and glial fibrillar acidic protein (GFAP) on serial section analysis. This suggests that Mn-SOD scavenger system is associated with the formation of senile plaques. On the other hand, Mn-SOD immunoreactivity was not significant in NFT-loaded neurons.
    [Abstract] [Full Text] [Related] [New Search]