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  • Title: The use of topical calcipotriene/calcipotriol in conditions other than plaque-type psoriasis.
    Author: Thiers BH.
    Journal: J Am Acad Dermatol; 1997 Sep; 37(3 Pt 2):S69-71. PubMed ID: 9344189.
    Abstract:
    BACKGROUND: Topical calcipotriene ointment has been approved for the treatment of plaque-type psoriasis. OBJECTIVE: This article explores the possible use of topical calcipotriene ointment in the treatment of nail and intertriginous psoriasis, palmoplantar and pustular psoriasis, Reiter's syndrome, pityriasis rubra pilaris, and disorders of keratinization. METHODS: The recent literature is reviewed. RESULTS: Recent reports suggest that certain ichthyoses (particularly the hyperproliferative variants) and keratodermas may respond to topical calcipotriene ointment. The activity of calcipotriene relates to a dose-dependent decrease in proliferation and an increase in terminal differentiation of keratinocytes. CONCLUSION: Patients with other disorders characterized by epidermal hyperproliferation may also be candidates for treatment. The use of calcipotriene in treating congenital hyperproliferative disorders is limited by the theoretical risk of hypercalcemia from absorption of the drug after application to extensive areas of skin.
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