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  • Title: Stimulation of TK1 lymphoma cells via alpha 4 beta 7 integrin results in activation of src-tyrosine- and MAP-kinases.
    Author: Uhlemann AC, Brenner B, Gulbins E, Linderkamp O, Lang F.
    Journal: Biochem Biophys Res Commun; 1997 Oct 09; 239(1):68-73. PubMed ID: 9345271.
    Abstract:
    The lymphocyte integrin alpha 4 beta 7 is a cell surface adhesion receptor involved in initiating lymphocyte homing to gut-associated/mucosal lymphoid tissues by binding the mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Other known ligands are vascular cell adhesion molecule-1, fibronectin, and the alpha 4 integrin chain itself. Here, we demonstrate that stimulation of the alpha 4 beta 7 integrin through its alpha 4 subunit (mAb R1-2), beta 7 subunit (mAb M293), or the combinatory epitope (mAb DATK32) enhances tyrosine phosphorylation of several cellular proteins in the murine TK1 lymphoma cell line. The two src-kinases p56lck and p59fyn were identified as possible mediators and substrates of the detected tyrosine phosphorylation. Furthermore, we observed activation of the MAP-kinases ERK1/2.
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