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  • Title: Visualizing cortical activation during mental calculation with functional MRI.
    Author: Rueckert L, Lange N, Partiot A, Appollonio I, Litvan I, Le Bihan D, Grafman J.
    Journal: Neuroimage; 1996 Apr; 3(2):97-103. PubMed ID: 9345480.
    Abstract:
    Cortical activation during arithmetic calculation (silent subtraction by sevens) was compared to that observed during a control condition for which subjects were required to count forward by ones. Nine normal subjects underwent 1.5-T functional magnetic resonance imaging while performing these tasks. All subjects showed bilateral premotor, posterior parietal, and prefrontal cortex activation during serial calculation. There was a large degree of individual variation in activation outside of these areas. These results confirm the role of posterior parietal cortex in arithmetic calculation and implicate other regions, including prefrontal cortex.
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