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  • Title: Evidence of rare codon clusters within Escherichia coli coding regions.
    Author: Phoenix DA, Korotkov E.
    Journal: FEMS Microbiol Lett; 1997 Oct 01; 155(1):63-6. PubMed ID: 9345765.
    Abstract:
    It is known that there is a high occurrence of rare codons at the start of coding region. Here it is shown that although the remainder of the gene is likely to contain a relatively low number of rare codons, rare and non-rare codons do not form a random sequence. It is apparent that throughout the coding region there is a higher than expected number of rare codon clusters. For example once a rare codon has occurred there is a greater chance than expected of the next six codons containing another rare codon. This non-random distribution implies that rare codons may have an as yet unidentified biological role.
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