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  • Title: Relaxation of the ovine isolated iris sphincter by adenosine receptor agonists: lack of effect of adenosine A1 and A2 receptor antagonists.
    Author: Hourani SM, Smith NC, Nettell JJ, Hall JM.
    Journal: Eur J Pharmacol; 1997 Sep 03; 334(1):95-8. PubMed ID: 9346333.
    Abstract:
    The effects of adenosine receptor ligands on the tone of the ovine isolated iris sphincter were investigated, and adenosine analogues were found to relax the carbachol-contracted tissue in a concentration-dependent manner with an order of potency of 5'-N-ethylcarboxamidoadenosine > or = 2-(p-(2-carboxyethyl)phenylethylamino)-5'-N-ethylcarboxamidoadenos ine (CGS 21680) > or = N6-cyclopentyladenosine > adenosine, consistent with activation of an adenosine A2A receptor. However, these responses were not inhibited by the non-selective adenosine A1/A2 receptor antagonist 8-p-sulphophenyltheophylline (50 microM), the selective adenosine A2A/A1 receptor antagonist N-[2-(dimethylamino)ethyl]-N-methyl-4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3- dipropyl-1H-purin-8-yl)benzenesulphonamide (PD 115,199) (0.1 microM) or the non-xanthine adenosine A2A receptor antagonist (4-(2-[7-amino-2-(2-furyl) [1,2,4]-triazolo[2,3-a][1,3,5]triazin-5-yl-amino]ethyl)phenol) (ZM 241385) (0.1 microM). The relaxations cannot therefore be mediated by activation of adenosine A1, A2A or A2B receptors.
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