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  • Title: Trihexyphenidyl treatment of clozapine-induced hypersalivation.
    Author: Spivak B, Adlersberg S, Rosen L, Gonen N, Mester R, Weizman A.
    Journal: Int Clin Psychopharmacol; 1997 Jul; 12(4):213-5. PubMed ID: 9347382.
    Abstract:
    The objective of this study was to investigate the efficacy of the anticholinergic agent trihexyphenidyl in the treatment of clozapine-induced hypersalivation. Fourteen chronic schizophrenic patients who exhibited nocturnal hypersalivation during clozapine treatment were coadministered trihexyphenidyl (5-15 mg/day, at bedtime) for 15 days. Salivation was assessed by a single-item 5-point scale. A reduction of 44% in the reported nocturnal hypersalivation was observed after trihexyphenidyl treatment. These results indicate that at least some chronic schizophrenic patients with clozapine-induced nocturnal hypersalivation may benefit from anticholinergic treatment.
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