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  • Title: Convulsive thresholds and the activity of anticonvulsants in electroseizure test. The role of serotoninergic system.
    Author: Przegaliński E.
    Journal: Pol J Pharmacol Pharm; 1976; 28(2):143-55. PubMed ID: 934946.
    Abstract:
    The effect of different compounds modifying the activity of serotoninergic system on the convulsive threshold and on anticonvulsant action of phenyltoin (PHEN) phenobarbital (PHB), m-bromophenyl succinimide (BPHSI) and acetazolamide (ACA) in electroseizure test was studied. The obtained results suggest that 5-HT plays a significant role in the convulsive threshold and in ACA anticonvulsant action. No correlation, however, was observed between anticonvulsant action of the studied drugs and their influence on 5-HT level in brain.
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