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  • Title: Aspiration and imprint cytopathology of salivary duct carcinoma.
    Author: Domson KK, Wakely PE.
    Journal: Cancer; 1997 Oct 25; 81(5):281-6. PubMed ID: 9349515.
    Abstract:
    BACKGROUND: Salivary duct carcinoma (SDC) is a highly malignant primary epithelial neoplasm of the salivary glands. The histology of this lesion resembles that of cribriform and comedo-type intraductal carcinoma of the breast, yet the cytopathology of salivary duct carcinoma has been described in only a few instances in the past. METHODS: The authors report two cases of SDC diagnosed by fine-needle aspiration biopsy and one case imprinted after resection. The cytologic features that may permit diagnosis of this entity are described. RESULTS: Cytologic features include variably cellular smears containing loose clusters of cribriform and glandlike aggregates; monomorphic polygonal cells with round-to-oval nuclei; abundant, finely granular cytoplasm; indistinct nucleoli; and variable necrosis. CONCLUSIONS: The cytologic findings for SDC are relatively unique and may allow for its specific diagnosis on aspiration cytopathology.
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