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  • Title: Effect of 4-methylumbelliferone on cell-free synthesis of hyaluronic acid.
    Author: Nakamura T, Funahashi M, Takagaki K, Munakata H, Tanaka K, Saito Y, Endo M.
    Journal: Biochem Mol Biol Int; 1997 Oct; 43(2):263-8. PubMed ID: 9350333.
    Abstract:
    Human skin fibroblasts were cultured in the presence of 0.5 mM 4-methylumbelliferone for 12 h, and cell-free synthesis of hyaluronic acid was performed using membrane-rich fraction from the cells. The preincubation of the cells with 4-methylumbelliferone reduced hyaluronic acid synthesis to 15% of that of non-preincubated cells, although its chain length was not changed. On the other hand, without preincubation of the cells with 4-methylumbelliferone, hyaluronic acid synthesis was not changed even when 4-methylumbelliferone was added directly to the reaction mixture. These results suggest that 4-methylumbelliferone represses the expression of hyaluronic acid synthase on the cell surface.
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