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  • Title: The increased level of PDGF-A contributes to the increased proliferation induced by mechanical stimulation in osteoblastic cells.
    Author: Wang W, Zhuang H, Levitz CL, Fan H, Seldes RM, Tahernia AD, Brighton CT.
    Journal: Biochem Mol Biol Int; 1997 Oct; 43(2):339-46. PubMed ID: 9350341.
    Abstract:
    Mechanical stimulation can prompt healing of bone fractures. However, it is largely unknown how osteogenesis is promoted by mechanical stimulation. In this study, we found that mechanical strain-induced proliferation of osteoblastic cells (MC3T3-E1) accompanied increased levels of platelet-derived growth factor-A (PDGF-A) mRNA, determined by quantitative reverse transcription/polymerase chain reaction. In addition, neomycin and W-7, which blocked mechanical strain-induced proliferation of the osteoblast cells, also blocked mechanical stimulation-induced elevation of PDGF-A mRNA. Finally, an antibody against PDGF can inhibit physical stimulation-induced proliferation of MC3T3-E1 cells, suggesting that the increased MC3T3-E1 cells produced by mechanical stimulation at least partially depends on the increased activity of PDGF.
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