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  • Title: [Treatment of diabetes mellitus with long-acting biguanides].
    Author: Kliachko VR, Perelygina AA, Mazovetskiĭ AG, Slavina LS.
    Journal: Probl Endokrinol (Mosk); 1976; 22(3):22-6. PubMed ID: 935083.
    Abstract:
    The paper discusses of the results of treatment with preparations of phenylethylbiguanide (dibotin, meltrol, dipar, dibophen-retard), of butylbiguanide (silubin-retard, buforming-retard) and of dimethyl-biguanide (glucophage-retard). All these preparations were of prolonged action. The treatment was carried out in 242 patients. The saccharolytic action of the active agent contained in one tablet of each type of biguanide was approximately the same. Biguanides of prolonged action were highly effective in obese patients with diabetes mellitus of moderate severity. The best results were obtained in complex treatment with biguanides of prolonged action together with sulfonylurea preparations of the second generation. There were noted almost no toxic reactions from the use of biguanides up to 2 tablets a day.
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