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  • Title: [Specific antagonism between angiotensin II and several of its analogs].
    Author: Myshliakova NV, Auna ZP, Indulen IuI, Klusha VE, Chipens GI.
    Journal: Probl Endokrinol (Mosk); 1976; 22(3):85-9. PubMed ID: 935097.
    Abstract:
    The authors studied comparatively the properties of two angiotensin II analogues, a new compound (1-hydantoin acid, 5-valine, 8-alanine)-angiotensin II (compound III) and (1-asparagine, 5-valine, 8-alanine)-angiotensin II (compound II), as of the myotropic action of angiotensinamide (these experiments were conducted on the rat isolated ascending colon); pressor action of the hormone was investigated in experiments on anesthetized rats. A competitive character of the antagonism--within the range of low concentrations of the analogues--10(-10)--10(-9) M/l--was revealed in vitro. No antagonism was expressed against the nonspecific myotropic agents--acetylcholine and bradykinin. In vivo compounds II and II manifested the antagonistic action against angiotensinamide beginning from the doses of 100 and 50 gamma/kg, respectively.
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