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  • Title: Pathogenesis of dengue virus diseases: missing pieces in the jigsaw.
    Author: Bielefeldt-Ohmann H.
    Journal: Trends Microbiol; 1997 Oct; 5(10):409-13. PubMed ID: 9351178.
    Abstract:
    The mechanisms involved in the pathogenesis of dengue hemorrhagic fever and dengue shock syndrome remain unresolved. Antibody-dependent enhancement of infection has long been thought to play a central role; however, this remains unverified. The alternative hypothesis that virus variation, virulence and dynamics may account for severe dengue disease, particularly in children, should be considered.
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