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  • Title: Indolic tryptophan metabolism in uraemia.
    Author: Byrd DJ, Berthold HW, Trefz KF, Kochen W, Gilli G, Schärer K, Schüler HW, Asbach HW.
    Journal: Proc Eur Dial Transplant Assoc; 1976; 12():347-54. PubMed ID: 935125.
    Abstract:
    Tryptophan and some indolic metabolites were studied in urine, plasma and dialysate of uraemic patients using thin-layer- and high-pressure liquid chromatography. Some new metabolites: indole-3-carboxylic acid, indole-3-carbaldehyde, indolelactic acid and N-acetyltryptophan were detected. Levels of the latter two metabolites in urine, dialysate and especially plasma suggest increased transamination of tryptophan and a possible defect in renal amino acid acylase in uraemia.
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