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  • Title: Pleurectomy/decortication in the setting of multimodality treatment for diffuse malignant pleural mesothelioma.
    Author: Rusch VW.
    Journal: Semin Thorac Cardiovasc Surg; 1997 Oct; 9(4):367-72. PubMed ID: 9352954.
    Abstract:
    Pleurectomy/decortication is a frequently performed operation for patients with diffuse malignant pleural mesothelioma (DMPM). It has a low surgical mortality rate (less than 5%), but is associated with a significant risk of local recurrence. To date, intensive adjuvant radiation or chemotherapy has not diminished that risk. Despite these disappointing results, pleurectomy/decortication may still be the best treatment option for some patients, particularly those with early stage disease whose medical condition precludes pneumonectomy. The role of pleurectomy/decortication in conjunction with newer treatment strategies such as neoadjuvant therapy or gene therapy warrants investigation.
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