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  • Title: Quantitative trait loci analysis affecting contextual conditioning in mice.
    Author: Caldarone B, Saavedra C, Tartaglia K, Wehner JM, Dudek BC, Flaherty L.
    Journal: Nat Genet; 1997 Nov; 17(3):335-7. PubMed ID: 9354801.
    Abstract:
    In an extensive backcross of mice between C3H/HeJ (C3H) and C57BL/6J (B6), we sought to map genes that influence learning and memory as measured by performance in a contextual fear-conditioning paradigm. Our results indicate that there are several genetic regions that have a strong influence on performance in this paradigm. The strongest influences map to the proximal and distal ends of chromosome 1 (lod scores of 5.14 and 4.76, respectively). Other chromosomal regions (chromosomes 3, 7, 8, 9 and 18) were also identified as candidates for regions containing genes influencing contextual fear conditioning, with lod scores ranging from 1.8 to 2.7.
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