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  • Title: Antenatal diagnosis and treatment of fetal hypothyroidism. A report of two cases.
    Author: Bruner JP, Dellinger EH.
    Journal: Fetal Diagn Ther; 1997; 12(4):200-4. PubMed ID: 9354877.
    Abstract:
    Fetal goiter in the presence of maternal Graves' disease can signify either hyperthyroidism or hypothyroidism in the fetus. Two patients with Graves' disease taking propylthiouracil were found to have a fetal goiter on a prenatal sonogram. Fetal blood sampling identified hypothyroidism in both instances. Administration of intraamniotic thyroxine resulted in rapid resolution of the goiter, normalization of subsequent fetal thyroid studies, and delivery of a euthyroid fetus. Cordocentesis allows accurate diagnosis and follow-up of fetal thyroid dysfunction and prompt initiation of appropriate therapy.
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