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  • Title: Juvenile chronic arthritis--bone mineral density in relation to corticosteroid therapy.
    Author: Bayer M, Stĕpán J, Nĕmcová D, Kutílek S, Hoza J.
    Journal: Acta Univ Carol Med (Praha); 1994; 40(1-4):33-5. PubMed ID: 9355669.
    Abstract:
    Bone demineralization often accompanies juvenile chronic arthritis (JCA). Fourteen patients with confirmed diagnosis of JCA had their bone mineral density (BMD) measured with the use of dual photon X-ray absorptiometry. The results obtained were compared to the Lunar BMD DPXA standards. Seven patients received Prednisone in doses of more than 0.16 mg/kg/day for more than 6 months and 7 patients (sex and age matched) never received any steroids at all. In the first group BMD was decreased in 7 patients (100%), in the second group BMD was mildly decreased in 2 patients (28%). Due to the difference in BMD in both groups, it is obvious that corticosteroids have substantial influence on bone demineralization in JCA.
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