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  • Title: Penetration of phenylacetic acid across the blood-cerebrospinal fluid barrier.
    Author: Pedemonte WA, Mosnaim AD, Bulat M.
    Journal: Res Commun Chem Pathol Pharmacol; 1976 May; 14(1):111-6. PubMed ID: 935645.
    Abstract:
    Labeled phenylacetic acid (14C-PAA) penetrates blood-cerebrospinal fluid (CSF) barrier in cats only under a high gradient of concentration; under these conditions the administration of large doses of either PAA or probenecid decreases the plasma:CSF 14C-PAA ratio. 14C-PAA is quickly removed from the CSF and blood and is excreted into urine; this excretion is blocked by probenecid. It appears, therefore, that PAA crosses the blood-CSF barrier with difficulty and that is secreted by the kidney.
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