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  • Title: Computerized image analysis of sister chromatid exchanges in Chinese hamster ovary cells.
    Author: Schunck C, Obe G.
    Journal: Mutat Res; 1997 Oct 06; 379(2):233-9. PubMed ID: 9357552.
    Abstract:
    In this paper we show that sister chromatid exchanges (SCE) can be analysed by computer-supported determination of areas and shapes of darkly stained chromatid sections. In combination with appropriate statistical analyses, our method leads to measurements of SCE frequencies in neocarzinostatin-treated Chinese hamster ovary cells which are nearly as precise as the ones obtained by classical microscopical analyses. We discuss our data as an approach to the development of a fully automated SCE scoring system.
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