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  • Title: Positioning of 72 potentially full size LTRs of human endogenous retroviruses HERV-K on the human chromosome 19 map. Occurrences of the LTRs in human gene sites.
    Author: Vinogradova T, Volik S, Lebedev Yu, Shevchenko Yu, Lavrentyeva I, Khil P, Grzeschik KH, Ashworth LK, Sverdlov E.
    Journal: Gene; 1997 Oct 15; 199(1-2):255-64. PubMed ID: 9358063.
    Abstract:
    Seventy-two near full size long terminal repeats (LTRs) of human endogenous retrovirus of K-family (HERV-K) have been precisely located on the metric map of human chromosome 19. The LTR-related sequences were identified and assigned to cosmids by hybridization with two independent chromosome 19 specific cDNA clones corresponding to different parts of U3 region of LTR of HERV-K. The presence of full-size LTR sequences in a cosmid was further verified by PCR assay with a pair of primers complementary to the termini of the LTR. Coincidences of the LTR and the known genes positions are discussed.
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