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  • Title: Isotropic diffusion-weighted and spiral-navigated interleaved EPI for routine imaging of acute stroke.
    Author: Butts K, Pauly J, de Crespigny A, Moseley M.
    Journal: Magn Reson Med; 1997 Nov; 38(5):741-9. PubMed ID: 9358448.
    Abstract:
    An interleaved echo-planar imaging (EPI) technique is presented for the rapid acquisition of isotropic diffusion-weighted images of stroke patients. Sixteen isotropic diffusion-weighted images at three b values are acquired in less than 3 min. A spiral navigator echo is used to measure the constant and linear phase shifts across the head in both the x and y directions which result from motion during the isotropic diffusion- sensitizing gradients. The measured k-space errors are corrected during a gridding reconstruction. The gridding kernel has a constant width in kx and a variable width in ky which eliminates variable data-density ghosts. The resulting isotropic diffusion-weighted images have excellent lesion-to-normal brain contrast, very good spatial resolution, and little sensitivity to susceptibility effects in the base of the brain. Examples of diffusion-weighted images and ADC maps from several stroke patients are shown.
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